Ancient Trikki, an important city of the Thessalian tetrarchy of Estiaotida, sprawled between the Lithaios river – which still crosses today’s modern city – and on the hill “Kastro” where probably the ancient citadel was. In the city there was one of the oldest medical centers of Asclepius, that ancient Trikki was known in antiquity. The earliest proof about Trikki is in the Homeric List of Ships, which mentions that the city participated in the expeditionary force of the Greeks in the Trojan War with 30 ships and leaders of the two sons of Asclepius, Mahaonas and Podalerios, who had been taught Medicine by their father. For the beginnings of the city of historical times the excavations are poor and the written sources sparse. The earliest confirmed excavation of the city dates back to the Bronze Age and is located in the area of ​​the present archaeological site of Trikala. In test sections there was found ceramics indicating that the western slopes of the ancient acropolis had been inhabited since the Early Bronze Age (3300 BC) until the Mycenaean era. Unfortunately, there are not architectural remains. Ceramics that were found in test sections, indicates uninterrupted habitation from the early geometric years to the classical times. The connection of the city with Asclepius – the antiquity of the city was known as «αρχαιότατον και επιφανέστατον» (“ancient and prominent”) according to the geographer of the 1st century. B.C. Strabo – gave Trikki a special radiance in Greece. Today, the largest part of the ancient city is covered by the homonymous modern city, as its habitation has been uninterrupted until nowadays. The archaeological excavation began to bring to light and reconstruct the image of ancient Trikki from the late 19th century, when (following the excavation of the Asclepius of Epidaurus) the researchers were interested in the revelation and the same name of the ancient Asclepius of Trikki. The archaeological excavations that were carried out on the site on adjacent, private plots from 1902 to 1992 had a rescue character and brought to light three buildings of early Roman times and one belonging to the Byzantine period.